Press Release: The moral imperative to research editing embryos: The need to modify Nature and Science

The first study in which the DNA of human embryos was intentionally modified has been published in the journal Protein & Cell, released on Saturday. This research is significant because it may be an important step toward a world where we are free from genetic disease. However allegations that Nature and Science refused to publish this research on ethical grounds are concerning.

The Director of the Oxford Uehiro Centre for Practical Ethics Professor Julian Savulescu has called on Nature and Science to clearly explain their editorial decisions in relation this study.

“If these studies were rejected for ethical reasons we need to know what these reasons are.” Professor Savulescu said.

“There was absolutely no potential for this research to directly result in the birth of a modified human and it is unclear how the study could have harmed or wronged anyone.

Nature should explain why it deems this research ethically problematic, and yet publishes other controversial research, involving viruses, with the potential to directly kill millions of people.” Continue reading

The moral imperative to research editing embryos: The need to modify Nature and Science

Chris Gyngell and Julian Savulescu

Human genetic modification has officially progressed from science fiction to science.  In a world first, scientists have used the gene editing technique CRISPR to modify human embryos. While the study itself marks an important milestone, the reason it is truly extraordinary is the scientific community’s reaction to it. In refusing to publish this study on ethical grounds, the world’s two leading science journals Nature and Science, appear to be demonstrating a lack of clear and consistent thinking on ethical issues. Continue reading

Editing the germline – a time for reason, not emotion

Gyngell, Douglas, Savulescu

There are rumours in the scientific community that the first studies involving the genetic modification of a human embryo are about to be published.[1] If true this would be the first case of an experiment in which genes in germ cells (sperm and egg cells) have been intentionally modified.  This has caused some concerns in the scientific community due to the fact that these modification are potentially heritable.  A commentary in Nature, (written by four leading scientists and one philosopher) published an appeal that we “Don’t edit the human germ line”.  Science meanwhile published a commentary which outlines “A prudent path forward for genomic engineering and germline gene modification”. The fact that two of the world’s most prestigious journals are publishing commentaries on human genetic modification shows just how powerful gene editing techniques have become. The rapid speed with which these technologies have developed has taken the scientific community, and everyone else, by surprise. Just three years after the DNA cutting nuclease Cas-9 was first used to modify DNA, scientists have been able to make heritable modifications to yeast, plants, mice, rats, pigs and even primates. It has been claimed that experiments conducted in China, currently under review, have used these same technologies to modify the DNA of human embryos.[2] Continue reading

Smart pills vs. motivation pills – is one morally worse than the other?

Imagine a huge pile of unwashed dishes reminds you that you should clean your kitchen. Would you rather take a pill that increases your ability to clean very elaborately or one that helps you get off the couch and actually bring yourself to start cleaning? No hard decision for me…

Certain substances like methylphenidate can not only enhance cognition, but also motivation or, to be more precise, self-regulation. This is not too surprising as treating conditions associated with decreased self-regulation like ADHD often is a main purpose of such medication. Continue reading

Where there’s a will there’s a way: Enhancing motivation

by Hannah Maslen, Julian Savulescu and Carin Hunt

A study examining pharmaceutical cognitive enhancement found that participants’ subjective enjoyment of various memory and problem-solving tasks was significantly greater when they had taken modafinil (a drug originally developed for narcolepsy) compared with placebo, but that mood ratings overall were not affected (Muller at al 2013). The authors of the paper therefore concluded that, in addition to the various performance effects, ‘an important finding of this study is that there was a striking increase in task motivation’. Whilst a lot of attention has been paid to the ethical implications of enhancing cognitive performance, much less has been paid to the striking task-motivation finding. We suggest, however, that motivation enhancement might be the more contentious effect, from an ethical point of view. Continue reading

On the supposed distinction between culture and religion: A brief comment on Sir James Munby’s decision in the matter of B and G (children)

On the supposed distinction between culture and religion: A brief comment on Sir James Munby’s decision in the matter of B and G (children)

By Brian D. Earp (@briandavidearp)


What is the difference between “culture” and “religion” … ? From a legal standpoint, this question is important: practices which may be described as being ‘religious’ in nature are typically afforded much greater protection from interference by the state than those that are understood as being “merely” cultural. One key area in which this distinction is commonly drawn is with respect to the non-therapeutic alterations of children’s genitals. When such alteration is done to female children, it is often said to be a “cultural” practice that does not deserve legal protection; whereas, when it is done to male children, it is commonly said to be a “religious” practice – at least for some groups – and must therefore not be restricted (much less forbidden) by law.

Is this a valid distinction?

Continue reading

Bentham and butterflies

Rampisham Down, in West Dorset, is a Site of Special Scientific Interest. But it soon won’t be. In a decision of dazzling stupidity, the local planning committee has said that it can be covered with over 100,000 solar panels. It accepted that renewable energy was a Good Thing and, in effect, that the loss of biodiversity occasioned by the panels was a price worth paying for the sun-farmers’ contribution to the battle against climate change.

Environmentalists, normally on the side of alternative energy, have been loud in their denunciation of the decision. A good example is Miles King in the Guardian: He observes: ‘….stopping biodiversity loss is as important as stopping global warming.’

Well, no it’s not. The crassness of the decision at Rampisham doesn’t alter the stark fact that  if global warming isn’t stopped, we won’t have any biodiversity of any kind to preserve. The planners were crass because there are plenty of other, better places to put the panels. But their view of the big picture is correct. Continue reading

What are the ethics of using brain stimulation technologies for ‘enhancement’ in children?

New open access publication: announcement:

In a recently published article, Hannah Maslen, Roi Cohen Kadosh, Julian Savulescu and I present an argument about the permissible (and not-so-permissible) uses of non-invasive brain stimulation technology in children. We consider both children who may be suffering from a specific neurological disorder, for whom the stimulation is intended as a ‘treatment’, and those who are otherwise healthy, for whom the stimulation is intended as ‘enhancement’. For the full article and citation, see here:

Maslen, H., Earp, B. D., Cohen Kadosh, R., & Savulescu, J. (2014). Brain stimulation for treatment and enhancement in children: An ethical analysisFrontiers in Human Neuroscience, Vol. 8, Article 953, 1-5. Continue reading

Mindfulness meditation and implicit bias

A recent study purports to demonstrate that mindfulness meditation techniques can reduce implicit biases. Affecting all manner of interpersonal interactions, implicit biases are unconscious attitudes or associations that influence our understanding, behavior and decisions. Implicit biases can be revealed using implicit association tests (IATs), which often measure the degree to which a participant associates particular stimuli (e.g. white or black faces) with negative and positive words by recording the speed and accuracy with which words are categorized when presented alongside ‘congruous’ or ‘incongruous’ stimuli. For example, white people are better at categorizing positive words when they presented alongside white, rather than black faces and better at categorizing negative words when they are presented alongside black, rather than white faces. Crucially, these implicit biases often do not correspond to participants’ explicit, reported attitudes to racial or other demographic minorities: even the most fervent (white, young) egalitarian can display implicit bias against black or elderly faces.

In their study, Lueke and Gibson sought to investigate whether mindfulness meditation could reduce implicit associations. Continue reading

Lying to children

A study published this month shows that school-aged children are more likely to lie to an adult if that adult had recently lied to them. The British Psychological Society’s Research Digest summarizes the study here.

Hays and Carver took school-aged (and preschool-aged) children and assigned them to one of two experimental conditions. In the first condition – the lie condition – the child was told that there was a large bowl of sweets in the experiment room when in fact there was no such bowl. Continue reading


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