Skip to content

Mackenzie Graham

Japan to Allow Human-Animal Hybrids to be Brought to Term

By Mackenzie Graham

The article was originally published at the Conversation

Around the world thousands of people are on organ donor waiting lists. While some of those people will receive the organ transplants they need in time, the sad reality is that many will die waiting. But controversial new research may provide a way to address this crisis.

Japan has recently overturned its ban on the creation of human-animal hybrids, or “chimeras”, and approved a request by researchers from the University of Tokyo to create a human-mouse hybrid.

Scientists will attempt to grow a human pancreas inside a mouse, using a certain kind of stem cell known as “induced pluripotent stem cells”. These are cells that can grow into almost any kind of cell. The stem cells will be injected into a mouse embryo, which has been genetically modified to be incapable of producing a pancreas using its own cells. This hybrid embryo is then implanted in a mouse surrogate and allowed to grow. The goal is to eventually grow a human pancreas in a larger animal – such as a pig – which can be transplanted into a human.

Read More »Japan to Allow Human-Animal Hybrids to be Brought to Term

Baby, It’s Cold Outside

By Mackenzie Graham

In late November, a radio station in Cleveland Ohio announced it would be removing the song ‘Baby, It’s Cold Outside’ from its holiday playlist, in response to listener complaints. Several other radio stations followed, including Canadian broadcasters Bell Media, CBC Radio and Rogers Media. These decisions proved divisive among listeners, however, with many of the US broadcasters, as well as the CBC, quickly reversing course and reinstating the song after conducting online listener polls.

The song was written in 1944 by Frank Loesser, as a duet that he regularly performed with his wife Lynn Garland at Hollywood celebrity parties. In 1949, Loesser sold the song to MGM Studios, who used it in the film Neptune’s Daughter, where it won the Academy Award for Best Original Song that same year. It has been re-recorded by more than 50 artists since that time, most recently in 2018, and is a staple of popular radio during the Christmas season, due to its wintery theme.

In the lyrics of the song, a party guest (typically sung by a female voice) and the party host (typically a male voice) sing back and forth about whether the guest should stay for ‘one more drink,’ or venture home (despite it being, presumably, quite cold outside). The female voice sings lines like ‘I ought to say no, no, no’, ‘what’s in this drink’, ‘you’re very pushy you know’, and ‘the answer is no’, while the male voice sings lines like ‘mind if I move in closer’, ‘what’s the sense of hurting my pride’, and ‘gosh your lips look delicious.’

Read More »Baby, It’s Cold Outside

UK Supreme Court Decision Means Patients No Longer Forced to Live

By Mackenzie Graham

On July 30, The UK’s Supreme Court ruled that there is no requirement to obtain court approval before withdrawing clinically assisted nutrition and hydration (CANH), when there is agreement between physicians and the family that this is in the best interests of the patient.

In the judgement, Lady Black writes:

“If the provisions of the MCA [Mental Capacity Act] 2005 are followed and the relevant guidance observed, and if there is agreement upon what is in the best interests of the patient, the patient may be treated in accordance with that agreement without application to the court.”

Until now, requests to withdraw CANH needed to be heard by the Court of Protection to determine if withdrawing treatment was in the patient’s best interest. In addition to being emotionally difficult for families, this is a time-consuming and expensive process, and often results in the patient dying before a judgement is rendered.

I think this decision has much to be said in its favour. First, it means that when there is agreement that continued treatment is no longer in the best interests of a patient with a prolonged disorder of consciousness, these patients are no longer being ‘forced to live’ until the Court affirms that being allowed to die is in their best interests. In many cases, court decisions take months, meaning that a patient is forced to be kept alive, against their best interests and the wishes of their family. Making the decision to withdraw care from a loved one is highly distressing, and this is likely further compounded by the burden and distraction of court proceedings.

Read More »UK Supreme Court Decision Means Patients No Longer Forced to Live

Why It’s Important to Test Drugs on Pregnant Women

By Mackenzie Graham

Crosspost from The Conversation. Click here to read the full article.

The development of accessible treatment options for pregnant women is a significant public health issue. Yet, very few medications are approved for use during pregnancy. Most drug labels have little data to inform prescribing decisions. This means that most medicines taken during pregnancy are used without data to guide safe and effective dosing.

The United States Food and Drug Administration recently published draft ethical guidelines for how and when to include pregnant women in drug development clinical trials. These guidelines call for “the judicious inclusion of pregnant women in clinical trials and careful attention to potential foetal risk”. The guidelines also distinguish between risks that are related to the research and those that are not, and the appropriate level of risk to which a foetus might be exposed.Read More »Why It’s Important to Test Drugs on Pregnant Women

Facebook, Big Data, and the Trust of the Public

By Mackenzie Graham

Facebook CEO Mark Zuckerburg recently appeared before members of the United States Congress to address his company’s involvement in the harvesting and improper distribution of approximately 87 million Facebook profiles —about 1 million of them British— to data collecting app Cambridge Analytica. In brief, Cambridge Analytica is a British political consulting firm, which uses online user data (like Facebook profiles), to construct profiles of subjects, which can then be used for what it calls ‘behavioural micro-targeting’; advertisements tailored to the recipient based on their internet activity. In 2016, Cambridge Analytica was contracted by Donald Trump’s presidential campaign, as well as the ‘Leave EU’ campaign prior to Britain’s referendum to leave the European Union.

Read More »Facebook, Big Data, and the Trust of the Public

Faster, Higher, Stronger…Happier? Olympic Athletes and the Philosophy of Well-Being

Written by Mackenzie Graham

Last Sunday marked the end of the 2018 Winter Olympics in Pyeongchang, South Korea. Olympic athletes train intensely for years in preparation for a single opportunity at winning gold. Unfortunately, most of them will not be successful. Many will have missed out on a medal by fractions of a second or tenths of a point, an ill-timed crash or fall, or a split-second mental error. In some respects, it hardly seems worth all of the effort and sacrifice, required to be an Olympic athlete (at least in most cases). To focus and train so long and so hard on a single task, only to fall just short of one’s goal, seems an irrational way to organize one’s life.

On the other hand, we might think that this pessimistic view completely misses the point, and that Olympic athletes are actually living some of the best lives possible. The philosophy of well-being is concerned with what things have ‘prudential value’; what things make a life good for the person who is living it? Three conceptions of well-being have largely dominated the philosophical literature. Hedonist views of prudential value hold that, at a fundamental level, the only thing that is ‘good for me’ (or anyone else), is the experience of pleasure, and the only thing that is bad for me is the avoidance of pain. The best life for me is the one which maximizes my experience of pleasure, and minimizes my experience of pain.

Read More »Faster, Higher, Stronger…Happier? Olympic Athletes and the Philosophy of Well-Being