chimeras

Japan to Allow Human-Animal Hybrids to be Brought to Term

By Mackenzie Graham

The article was originally published at the Conversation

Around the world thousands of people are on organ donor waiting lists. While some of those people will receive the organ transplants they need in time, the sad reality is that many will die waiting. But controversial new research may provide a way to address this crisis.

Japan has recently overturned its ban on the creation of human-animal hybrids, or “chimeras”, and approved a request by researchers from the University of Tokyo to create a human-mouse hybrid.

Scientists will attempt to grow a human pancreas inside a mouse, using a certain kind of stem cell known as “induced pluripotent stem cells”. These are cells that can grow into almost any kind of cell. The stem cells will be injected into a mouse embryo, which has been genetically modified to be incapable of producing a pancreas using its own cells. This hybrid embryo is then implanted in a mouse surrogate and allowed to grow. The goal is to eventually grow a human pancreas in a larger animal – such as a pig – which can be transplanted into a human.

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