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Biomedical Science

A tiny step forward

Researchers have managed to produce live-born mice (original article) descended from induced pluripotent stem cells (IPS cells), cells taken from adult animals and treated to become stem cells. That individuals could be produced from embryonic stem cells was already known, but this proves that the IPS cells can produce all kinds of cells in an adult body. Good news for people uneasy about the need for embryonic stem cells… or is it?

If one argues that it is wrong to use embryonic stem cells because embryos carry moral rights, then the question is whether the creation of IPS cells produce something that also has moral rights.

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Pandemic ethics: Mild flu and Tamiflu – the patient’s dilemma

In recent days there have been reports of a jump in the number of cases of H1N1 influenza (swine flu) in the UK. There have been 29 deaths associated with pandemic influenza in the UK, and there are 652 people in hospital in England with the flu. Faced with the prospect of primary health care services becoming overwhelmed, the government has set up a telephone hotline to allow those affected by the flu to access antiviral drugs (for example oseltamivir or Tamiflu) without needing to see a doctor. But there are also suggestions that not all patients with flu-like symptoms should be treated. Patients with mild or vague symptoms of the flu, without other medical conditions that put them at particular risk, may not be given medication.

This sets up a problem for patients who develop mild flu-like symptoms. Although there is only a small chance of them becoming seriously ill or dying from the flu it is possible that early treatment with anti-virals would reduce that risk. (Antivirals were only effective in trials if given in the first 48 hours of illness) Should they demand treatment from their doctor in the hope of avoiding a serious complication of influenza? Should they exaggerate their symptoms? If the doctor refuses, should the patient self-treat with medications that they have obtained privately (for example over the internet)? There is a form of the classic prisoner’s dilemma involved in such questions.

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Pandemic Vaccination: Who to Vaccinate?

Fears of the spread of pandemic influenza in the UK continue to grow. Three apparently previously healthy patients have died here. There are now plans for widespread immunisation later in the year – though initially this is likely to be restricted to those at highest risk, and those in 'vital' professions.

Who should be vaccinated? This is a question of distributive justice.

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Refusing Cochlear Implants: Is It Child Neglect?

Australian Graeme Clark developed the cochlear implant, or bionic ear, in the 1970s. It does not amplify sound but directly stimulates any functioning auditory nerves in the inner ear. The Australian Government has promised a screening program of all babies for deafness from 2011. At present, only 70 percent children who might benefit are picked up early. The earlier deafness is detected, the more effective treatment can be.

Lobby group Deaf Australia says the implant "implies that deaf people are ill or incomplete individuals, are lonely and unhappy, cannot communicate effectively with others and are all desperately searching for a cure for their condition. [This] demeans deaf people, belittles their culture and language and makes no acknowledgment of the diversity of lives deaf people lead, or their many achievements."
Some deaf parents have denied their children cochlear implants. Is this right?

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Is it Worth Living Longer?

Research recently published in Nature suggests that the drug rapamycin may have the potential to extend human life span by decades: http://news.bbc.co.uk/1/hi/health/8139816.stm

If the life is of ‘positive’ value, it might seem obvious that the drug is worth taking. But not everyone would agree. The Hellenistic philosopher Epicurus famously argued that, since it marks the end of conscious life, ‘death nothing to us’. Fearing death makes as much sense as regretting you weren’t around for all that time before your birth.

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Pandemic ethics: Party to the flu (or vigilante vaccination)

A public health expert has warned yesterday against the idea of swine-flu parties, arguing that it may undermine the fight against the emerging pandemic. But others, including James Delingpole in the Telegraph have embraced the idea, hoping that mild influenza now will protect against more serious illness later. Exposure parties might be thought of as a form of vigilante vaccination against influenza.

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Shining monkey, sadistic conclusion?

Japanese researchers have genetically modified marmoset monkeys, and demonstrated that the modification can be inherited by their offspring. The modification was the standard green fluorescent protein making the monkey's glow green under UV light, a marker to demonstrate that the modification worked (BBC shows a picture of their feet glowing "an eerie green", while the picture in Nature's News and Views shows the cute monkeys in normal light and the original paper shows both). The long-term aim is to be able to produce transgenic primates that could act as disease models for humans – many conditions do not map well onto mice and rats. But is it acceptable to introduce heritable illness conditions into animals?

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Self-control matters – but to what extent can it be taught?

Recently in
the news, a report published by the independent think-tank Demos reminds us of
the importance of the capacity for self-control (it also mentions empathy, to
which most of the following remarks apply) in determining life outcomes. It
argues that self-control lessons should be taught at school if children,
particularly from deprived backgrounds, are to be given the tools they need to
succeed in life – low-self-control has for instance been shown to positively
correlate with length of unemployment or criminal behaviour, and negatively
with academic achievement. The report echoes renewed interest in the United
States in a now famous experiment by Walter Mischel on deferred gratification,
dating back to the late 1960s. Mischel tested the capacity of a group of
four-year olds to resist the temptation to eat straightaway a marshmallow he
had given them. The children who were able to refrain turned out to be better
adjusted, more dependable and to do better academically on the whole later in
life.

 

The report
by Demos makes important points and its proposals deserve to be supported.
Nevertheless, even if they are put into practice, we might still feel concerned
about how effective we can expect them to be. There is indeed a body of
evidence suggesting that the capacity for self-control is to a large extent
genetically determined (Wright & Beaver, 2005; Beaver & al., 2009).

 

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Designer Babies and Slippery Slopes

Designer babies are in the news again. The LA Fertility Institutes, headed by a 1970s IVF pioneer, have offered the opportunity for potential parents to choose traits such as the eye and hair colour of their children: http://news.bbc.co.uk/1/hi/health/7918296.stm Unsurprisingly, slippery slope arguments have already begun to appear: http://www.theage.com.au/world/la-delivers-first-designerbaby-clinic-20090302-8meq.html Marcy Darnovsky, director of the Centre for… Read More »Designer Babies and Slippery Slopes