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Bioterrorism

Ethics of Ebola and Potentially Life-Saving Experimental Treatment

Summary: Patients potentially infected with Ebola have the right to experimental treatment outside of randomised controlled trials. Consent should be sought while they are competent if it is anticipated that they will lose competency through the disease. In the most extreme emergencies, experimental treatment could be given without consent in the public interest. However, in such extreme emergencies, such if the virus were to mutate to become very highly transmissible, selection of patients for such trials should be on a principle of justice. This would generally require selecting patients with the worst prognosis as initial subjects. Whilst the current outbreak has been declared an international health emergency, it does not warrant over-riding standard ethical principles of consent and autonomy.

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WHO are convening a meeting next week to discuss the use of untested treatments for the current Ebola outbreak, which it has declared to be an international public health emergency.

Dr Marie-Paule Kieny, Assistant Director-General at the World Health Organization explained “We are in an unusual situation in this outbreak. We have a disease with a high fatality rate without any proven treatment or vaccine,”

With a fatality rate of recent outbreaks at around 50%, and current treatments consisting of little more than rehydration, it is easy to see why this experimental approach is an attractive option. Jeremy Farrar, David Heymann and Peter Piot argued convincingly in favour of such measures.

However, there are a number of diseases which meet Dr. Kieny’s criteria of “a high fatality rate without any proven treatment or vaccine”. While Kieny is referring to infectious disease, sufferers of other diseases have campaigned for many years for access to untested medicines. Along with several colleagues, I wrote a paper on this subject with Les Halpin, who recently died from motor neurone disease, having campaigned for access to medicines for many years

The case for

I have argued that, when a patient is facing a certain death from an incurable disease, the relative safety that randomised controlled trials provide is unnecessary- especially when the payoff is a placebo group of patients who receive no benefit at all.

One common reason in support of randomised controlled trials is safety. This is true for most patients: patients for whom there are other good treatment options, or whose disease is not itself life-threatening. But for some patients, this concern is a cruel irony. Their disease is so overwhelmingly unsafe that any risk is outweighed by potential benefits. Udo Schuklenk reports Martin Delaney, a trial patient for AIDS who described the situation vividly:

It is as if I am in a disabled airplane, speeding downward out of control. I see a parachute hanging on the cabin wall, one small moment of hope. I try to strap it on, when a would be government employee reaches out and tears it off my back, admonishing, ‘You cannot use that! It does not have a Federal Aviation Administration sticker on it. We do not know if it will work’

Read More »Ethics of Ebola and Potentially Life-Saving Experimental Treatment

In defense of the double standard for chemical weapons

As the US and other nations gear up for war in Syria, the alleged use of chemical weapons by the Assad regime against civilians has received great, perhaps inordinate attention.  A little over a year ago, US President Barack Obama called the use of chemical weapons a “red line”, though was vague about what would happen if that line were crossed.  And while there were previous allegations of chemical weapons attacks, the most recent accusations concerning an attack in a Damascus suburb that killed hundreds seem to have been taken more seriously and will likely be used as a Causus Belli for air strikes against Assad’s forces in Syria.  Yet, some have argued that this focus on chemical weapons use is rather inconsistent.  Dominic Tierney at the Atlantic sarcastically comments, “Blowing your people up with high explosives is allowable, as is shooting them, or torturing them. But woe betide the Syrian regime if it even thinks about using chemical weapons!”  And Paul Whitefield at the LA Times inquires, “Why is it worse for children to be killed by a chemical weapon than blown apart by an artillery shell?”  These writers have a point.  But, while it may not be entirely consistent, I will argue that the greater concern over the use of chemical weapons compared with conventional weapons is justified.  Read More »In defense of the double standard for chemical weapons

Enlightened surveillance?

New York City contemplates using aerial drones for surveillance purposes, while North Korea buys thousands of cameras to spy on its impoverished population. Britain has so many cameras they cease being newsworthy. The stories multiply – it is trivial to note we are moving towards a surveillance society.

In an earlier post, I suggested surrendering on surveillance might be the least bad option – of all likely civil liberty encroachments,  this seemed the less damaging and hardest to resist. But that’s an overly defensive way of phrasing it – if ubiquitous surveillance and lack of privacy are the trends of the future, we shouldn’t just begrudgingly accept them, but demand that society gets the most possible out of them. In this post, I’m not going to suggest how to achieve enlightened surveillance (a 360 degree surveillance would be a small start, for instance), but just outline some of the positive good we could get from it. We all know the negatives; but what good could come from corporations, governments and neighbours being able to peer continually into your bedroom (and efficiently process that data)? In the ideal case, how could we make it work for us?Read More »Enlightened surveillance?

Personalised weapons of mass destruction: governments and strategic emerging technologies

Andrew Hessel, Marc Goodman and Steven Kotler sketches in an article in The Atlantic a not-too-far future when the combination of cheap bioengineering, synthetic biology and crowdsourcing of problem solving allows not just personalised medicine, but also personalised biowarfare. They dramatize it by showing how this could be used to attack the US president, but that is mostly for effect: this kind of technology could in principle be targeted at anyone or any group as long as there existed someone who had a reason to use it and the resources to pay for it. The Secret Service looks like it is aware of the problem and does its best to swipe away traces of the President, but it is hard to imagine this to be perfect, doable for old DNA left behind years ago, or applied by all potential targets. In fact, it looks like the US government is keen on collecting not just biometric data, but DNA from foreign potentates. They might be friends right now, but who knows in ten years…

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ASSASSINATING CITIZENS: How not to fight terror

By Brian Earp

See Brian’s most recent previous post by clicking here.

See all of Brian’s previous posts by clicking here.


In this ‘hour’ of danger: Civil liberties and the eternal threat of terror

NBC’s Pete Williams reports:

The U.S. government is legally justified in killing its own citizens overseas if they are involved in plotting terror attacks against America, Attorney General Eric Holder said Monday.

“In this hour of danger, we simply cannot afford to wait until deadly plans are carried out, and we will not,” he said in remarks prepared for a speech at Northwestern University’s law school in Chicago.

Pay attention to Mr. Holder’s choice of words here. This hour of danger? Excuse me: an “hour” is a bounded stretch of time – and not very long. But terrorism is a threat with no border – it has existed always, and will continue indefinitely. The “war on terror” cannot be won: you can kill a terrorist, sure, but you cannot eliminate a tactic. So let us not talk about an “hour.” This sort of speech is insidious. We all know that an hour takes sixty minutes and then it’s finished. But terrorism will present a “danger” forever.

Read More »ASSASSINATING CITIZENS: How not to fight terror

H5N1: Why Open the Stable Door?

Professor Paul Keim, who chairs the US National Science Advisory Board for Biosecurity, recently recommended the censoring of research that described the mutations which led to the transformation of the H5N1 bird-flu virus into a form that can be transmitted between humans through droplets in breath (in ferrets, the number of mutations required is frighteningly… Read More »H5N1: Why Open the Stable Door?

Experimenting with oversight with more bite?

It was probably hard for the US National Science Advisory Board for Biosecurity (NSABB) to avoid getting plenty of coal in its Christmas stockings this year, sent from various parties who felt NSABB were either stifling academic freedom or not doing enough to protect humanity. So much for good intentions.

The background is the potentially risky experiments on demonstrating the pandemic potential of bird flu: NSABB urged that the resulting papers not include “the methodological and other details that could enable replication of the experiments by those who would seek to do harm”. But it can merely advice, and is fairly rarely called upon to review potentially risky papers. Do we need something with more teeth, or will free and open research protect us better?

Read More »Experimenting with oversight with more bite?

Ferretting out fearsome flu: should we make pandemic bird flu viruses?

Scientists have made a new strain of bird flu that most likely could spread between humans, triggering a pandemic if it were released. A misguided project, or a good idea? How should we handle dual use research where merely knowing something can be risky, yet this information can be relevant for reducing other risks?

Read More »Ferretting out fearsome flu: should we make pandemic bird flu viruses?