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Stem Cell Trial for Stroke: Is It Cannabilizing Human Beings?

Stem Cell Trial for Stroke: Is It Cannabilizing Human Beings?

By Julian Savulescu

Reneuron has today announced the first transfer of stem cells in the UK to treat stroke. This follows quickly from Geron’s recent trial in spinal cord injury.

This is a historic moment which may be viewed in the same way as the first attempts to use antibiotics. Stem cells offer the door to entirely new form of medical treatment called regenerative medicine. When cells (the building blocks) or tissues of the body are damaged, they are generally not replaced. The dead tissue is replaced by scar that holds the rest of the organ together. So when a person has a stroke (or heart attack) a blood vessel to an area of brain is typically blocked and that area of the brain dies, being replaced by a scar that is functionless. Stem cell therapy offers the hope of replacing that dead or damaged tissue and cells with functioning new cells, in this case nerve cells. This trial is the very first stage to see if the transfer can be done safely.

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Lethal Ethics: When Philosophical Distinctions Kill

by Julian Savulescu

Teresa Lewis died on the 24th of September after being a lethal injection at the Greensville Correctional Centre in Virginia. The 41-year-old was convicted of plotting to kill her husband, Julian Lewis, and her stepson, Charles Lewis. She persuaded two men to carry out the murders in return for sex and money. The two men received life sentences. The execution went ahead in spite of protests from lawyers, celebrities and others who argued that she should have been given clemency because of her low IQ. Under US law, anyone with an IQ of 70 avoids the death penalty. Lewis was judged to have an IQ of 72.

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Focussing on diseases

Further to Julian’s article about Giving What We Can, an important part of helping people as much as possible is to find out which charities do the most good for a certain amount of money. This has been in the news recently with this article. It claims that we are missing out on doing a lot of good by focussing exclusively on certain high-profile diseases, while other diseases impose a greater burden and are much cheaper to treat. This raises the question of why some diseases get much more attention and support than others.

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Palmistry for the genome: genetic fundamentalism fights on

by Charles Foster
A recent paper in Social, Cognitive and Affective Neuroscience has the self-explanatory title Investigating the genetic basis of altruism: the role of the COMT Val158Met polymorphism. 1. The German authors aren’t as cautious in their claims as they should have been. They should have noted, nervously, the reception given to the infamous ‘God gene’ hypothesis,2 and entitled the paper something along the lines of ‘Some not very statistically significant correlations (from which we can’t begin to infer a causative relationship) between the COMT Val 158 Met polymorphism and some behaviour that might be markers of, amongst other things, being nice, whatever that means, ignoring other non-correlations with other more plausible markers of being nice.’

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Living in Plato’s Cave

Roger Crisp writes …

Plato’s allegory of the Cave (Republic 514a-517a) is perhaps the most famous image in the history of philosophy. Socrates describes a group of people living underground, bound so that they can see only in front of them. Behind them burns a fire, and in front of the fire there is a path with a barrier. Other people carry objects that project above the barrier, casting shadows on the wall in front of the prisoners. Naturally, the prisoners believe the truth to be nothing other than the shadows. ‘Strange prisoners’, says Socrates’s companion, Glaucon. ‘They’re like us’, Socrates answers.

This passage resonated with me during the recent mid-term elections here in the US. Liberal commentators were already expecting the worst after the landmark Supreme Court ruling in January, Citizens United v. Federal Election Commission, that the government cannot limit corporate funding of independent political broadcasts. That ruling was described by President Obama as ‘a major victory for big oil, Wall Street banks, health insurance companies, and the other powerful interests that marshal their power every day in Washington to drown out the voices of everyday Americans’. During the most recent elections, for example, Goldman Sachs (which you may remember received $10 billion in George Bush’s ‘Troubled Asset Relief Program’) gave the Republican party $1.2 million.

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Smoking and yellow teeth

With at least one airline announcing this week that it was stepping up screening on Yemeni passengers, I want to return to a topic I’ve touched on before: profiling.

What interests me is ‘rational profiling’. If a security guard believes, for no good reason, that members of racial/ethnic/national group R are more likely than average to pose a danger to the public, and this assumption is false, then we have a straightforward example of prejudice. But suppose there is indeed a greater risk from members of R? It then seems rational to focus more attention on R-members.

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Is your mobile phone part of your body?

by Rebecca Roache

The Frontline reports that sensors carried on the body of mobile phone users could soon be used to boost the UK’s mobile phone network coverage.  If only half of the 91% of the UK population who owns a mobile phone carried such sensors, then nearly half of the UK population would become part of a ‘body-to-body’ mobile phone network.

When technology becomes as wearable and ubiquitous as this, it raises some interesting questions about what sort of things people are, and about the division between the body and the surrounding environment.  What, after all, is a body?  At first glance, a person’s body is that mass of flesh, blood, and bone that we point to when we point to him or her: all very simple and straightforward.  Things get more complicated when we consider someone who has received an organ transplant.  Does a transplanted organ become part of the body of the person who receives it?  I would say so.  Assuming that the transplant is successful, it functions just like the organ it replaces; and an injury to the transplanted organ would be considered an injury to the recipient.  What about artificial devices that replace or supplement organs, like cochlear implants: do these count as body parts too?  I would imagine that most of us would be less willing to view such things as body parts.  However, if transplanted organs are to count as parts of the recipients’ bodies, refusal to accept cochlear implants as body parts seems mere prejudice.  Both enable the recipient’s body to perform a familiar and normal bodily function; and whilst a transplanted organ is – unlike a cochlear implant – undeniably a body part, it is pre-transplant no more a part of the recipient’s body than a cochlear implant.  So, perhaps we should consider cochlear implants to be body parts too.  If we accept something like a cochlear implant as a body part, though, what else might we feel bound to include?  What about less permanent replacement body parts, like false teeth and prosthetic limbs?  Tools that are not intended to replace body parts, but which nevertheless enable certain people to perform something like a familiar and normal bodily function, like wheelchairs?  Tools that enable people to perform functions that are not familiar and normal bodily functions, like pencils and screwdrivers?  Where do we draw the line between the body and the surrounding environment?

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Would you shock your brain to cope with culture shock?

In a paper published this last Friday, university of Oxford researchers showed that electrical stimulation may help people learn numbers faster (see Julian Savulescu’s post for Why Bioenhancement of Mathematical Ability Is Ethically Important). In the experiment, 20 min of stimulation to the right parietal lobe, a brain region shown previously to be important in numerical ability, caused subjects to faster learn the relative magnitudes ( i.e. which is bigger) of a set of nonsense symbols. Proper magnitude of each symbol was assigned beforehand by the experimenters.

When Cardiff University’s Christopher Chambers was reached for comment in the BBC article covering this paper, “he said that the study did not prove that the learning of maths skills was improved, just that the volunteers were better at linking arbitrary numbers and symbols and warned that the researchers needed to make sure other parts of the brain were unaffected.” Dr Chambers has an important cautionary point, but could learning the magnitudes of arbitrary symbols alone be beneficial? And how much would it matter if other brain areas were affected?

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Death Aquatic

Can science tell us how chefs should treat lobsters? The Independent this week implies it can. It seems that this is important to diners who want reassurance that their dinner has not been killed in a “barbaric” manner.

Science may of course discover the quickest or easiest method of killing. Norwegian researchers in particular have dedicated significant time to this research. Of methods including ice, nitrogen gas, freezing, gradual or rapid heating, piercing of ganglia, salt baths and carbon dioxide gas, apparently electricity is best. A commercial product, “Crustastun” offers the ability to replicate this in the kitchen. However, the retail cost of £2,500, puts this out of the reach of all but the richest, most gadget obsessed or humanitarian seafood lovers. But there is a more basic question: do lobsters really feel pain?

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