The reproducibility problem and the status of bioethics

There is a long overdue crisis of confidence in the biological and medical sciences. It would be nice – though perhaps rather ambitious – to think that it could transmute into a culture of humility.

A recent comment in Nature observes that: ‘An unpublished 2015 survey by the American Society for Cell Biology found that more than two-thirds of respondents had on at least one occasion been unable to reproduce published results. Biomedical researchers from drug companies have reported that one-quarter or fewer of high-profile papers are reproducible.’

Reproducibility of results is one of the girders underpinning conventional science. The Nature article acknowledges this: it is accompanied by a cartoon showing the crumbling edifice of ‘Robust Science.’

As the unwarranted confidence of scientists teeters and falls, what will – and what should – happen to bioethics?

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Behavioral Science, Public Policy, Ethics

The President of the United States has issued an executive order (see here) – government agencies are to use ‘insights’ from behavioral sciences to better serve the American people.

In my view this is a good thing. Science is our friend. Obama’s heart is in the right place. Nonetheless, the order raises a number of ethical and practical issues. Continue reading

ASMR and Absurdity

by Hannah Maslen and Rebecca Roache

In the past five years or so, a new phenomenon has emerged on the internet. ASMR videos allow you to spend around 40 minutes watching someone carefully unpack and repack a box, or listen to a detailed demonstration of ten different notebooks, or observe the careful folding of several napkins. If you think this is something that almost nobody would want to do, think again: a search on the term ‘ASMR’ on YouTube returns over 1.4 million videos, the most popular of which has been viewed 11.7 million times.

What is ASMR?

Autonomous sensory meridian response, or ASMR, is the pseudo-scientific name of a phenomenon that, according to thousands of anecdotal reports, various news reports, and a recently published academic survey, loads of people experience. ASMR refers to a pleasant tingling sensation in response to certain visual and/or auditory stimuli. Common triggers include the kind of close personal attention you get when someone cuts your hair, certain sounds like tapping or brushing, and perhaps most bizarrely of all, observing someone doing something trivial very carefully and diligently.

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Is this really me? Parasites and other humans’ cells in our brains change our psychology

Many people are suspicious about being manipulated in their emotions, thoughts or behaviour by external influences, may those be drugs or advertising. However, it seems that – unbeknown to most of us – within our own bodies exist a considerable number of foreign entities. These entities can change our psychology to a surprisingly large degree. And they pursue their own interests – which do not necessarily coincide with ours.

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Anorexia Nervosa and Deep Brain Stimulation: Philosophical Analysis of Potential Mechanisms

By Hannah Maslen, Jonathan Pugh and Julian Savulescu


According to the NHS, the number of hospital admissions across the UK for teenagers with eating disorders has nearly doubled in the last three years. In a previous post, we discussed some ethical issues relating to the use of deep brain stimulation (DBS) to treat anorexia nervosa (AN). Although the trials of this potential treatment are still in very early, investigational stages (and may not necessarily become an approved treatment), the invasive nature of the intervention and the vulnerability of the potential patients are such that anticipatory ethical analysis is warranted. In this post, we show how different possible mechanisms of intervention raise different questions for philosophers to address. The prospect of intervening directly in the brain prompts exploration of the relationships between a patient’s various mental phenomena, autonomy and identity. Continue reading

‘Competitive Altruism’ – Why attractive women are the most successful fundraisers

By Nadira Faber

Why do humans help others even when it is costly and nothing is to be expected in return? This question has not only developed into a classic in different empirical disciplines, but is also of high interest for fundraisers like charities who would like to know how to increase donations.

A study recently publish in Current Biology gives interesting real-life evidence for why people help that might sound like a paradox at first: ‘competitive altruism’.

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Press Release: The moral imperative to research editing embryos: The need to modify Nature and Science

The first study in which the DNA of human embryos was intentionally modified has been published in the journal Protein & Cell, released on Saturday. This research is significant because it may be an important step toward a world where we are free from genetic disease. However allegations that Nature and Science refused to publish this research on ethical grounds are concerning.

The Director of the Oxford Uehiro Centre for Practical Ethics Professor Julian Savulescu has called on Nature and Science to clearly explain their editorial decisions in relation this study.

“If these studies were rejected for ethical reasons we need to know what these reasons are.” Professor Savulescu said.

“There was absolutely no potential for this research to directly result in the birth of a modified human and it is unclear how the study could have harmed or wronged anyone.

Nature should explain why it deems this research ethically problematic, and yet publishes other controversial research, involving viruses, with the potential to directly kill millions of people.” Continue reading

The moral imperative to research editing embryos: The need to modify Nature and Science

Chris Gyngell and Julian Savulescu

Human genetic modification has officially progressed from science fiction to science.  In a world first, scientists have used the gene editing technique CRISPR to modify human embryos. While the study itself marks an important milestone, the reason it is truly extraordinary is the scientific community’s reaction to it. In refusing to publish this study on ethical grounds, the world’s two leading science journals Nature and Science, appear to be demonstrating a lack of clear and consistent thinking on ethical issues. Continue reading

Editing the germline – a time for reason, not emotion

Gyngell, Douglas, Savulescu

There are rumours in the scientific community that the first studies involving the genetic modification of a human embryo are about to be published.[1] If true this would be the first case of an experiment in which genes in germ cells (sperm and egg cells) have been intentionally modified.  This has caused some concerns in the scientific community due to the fact that these modification are potentially heritable.  A commentary in Nature, (written by four leading scientists and one philosopher) published an appeal that we “Don’t edit the human germ line”.  Science meanwhile published a commentary which outlines “A prudent path forward for genomic engineering and germline gene modification”. The fact that two of the world’s most prestigious journals are publishing commentaries on human genetic modification shows just how powerful gene editing techniques have become. The rapid speed with which these technologies have developed has taken the scientific community, and everyone else, by surprise. Just three years after the DNA cutting nuclease Cas-9 was first used to modify DNA, scientists have been able to make heritable modifications to yeast, plants, mice, rats, pigs and even primates. It has been claimed that experiments conducted in China, currently under review, have used these same technologies to modify the DNA of human embryos.[2] Continue reading

Smart pills vs. motivation pills – is one morally worse than the other?

Imagine a huge pile of unwashed dishes reminds you that you should clean your kitchen. Would you rather take a pill that increases your ability to clean very elaborately or one that helps you get off the couch and actually bring yourself to start cleaning? No hard decision for me…

Certain substances like methylphenidate can not only enhance cognition, but also motivation or, to be more precise, self-regulation. This is not too surprising as treating conditions associated with decreased self-regulation like ADHD often is a main purpose of such medication. Continue reading