genetic engineering

Cross Post: If you can screen for brown eyes, you should be able to edit out genetic disease

Not everyone’s choice of scarf. Shutterstock

It has long been known that cognitive diversity is important to collective performance. Diverse groups are more productive, more innovative and better at solving complex problems than less diverse groups. And recent research suggests that cognitive diversity also drives scientific progress.

Such research has direct implications for how we regulate reproductive technologies. Late last year, the London Sperm Bank was criticised for its decision to ban sperm donors who suffer from minor neurological disorders, including dyslexia and Asperger’s syndrome. Continue reading

Organ Mules

Julian Savulescu

While politicians wring their hands about sensible solutions to the organ shortage, scientists are progressing with genetic manipulations that may see human organs grown in pigs.

US scientists are creating novel life forms: “human pig chimeras”. These are a blend of human and pig characteristics. They are like mules who will provide organs to us. A mule is the offspring of a male donkey (jack) and a female horse (mare). Horses and donkeys are different species, with different numbers of chromosomes but they can breed together.

In this case, they take a skin cell from a person and turn it back in time to make stem cells capable of producing any cell or tissue in the body, “induced pluripotent stem cells.” They then inject this into a pig embryo. This makes a pig human chimera.

However they do a modification to the pig embryo first. They use gene editing, or CRISPR, to knock out the pig’s genes which produce an organ, say the pancreas. The human stem cells for the pancreas then make an almost entirely human pancreas in the pig human chimera. It functions like an organ mule. (The blood vessels are still porcine.)

In this way, your skin cell could grow a new liver, heart, pancreas, or lung.

This is a technique with wider possibilities: other US teams are working on a chimera –based treatment, this time for Parkinson’s disease which will use chimeras to create human neurones.

CRISPR is also credited with enhancing the safety of this technique, with the BBC reporting  that a Harvard team were able to use the new and revolutionary technique to remove copies of a pig retrovirus.

Safety is always a major concern when science crosses new boundaries. But even if a sufficient guarantee of safety could be reached, are there ethical problems?

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Prometheus and the Drive to Mastery

Writers who express caution about the over-enthusiastic embrace of new technologies, such as Michael Sandel, who worries about human enhancement and genetic engineering, and Clive Hamilton, who worries about geoengineering, sometimes warn us about the ‘Promethean attitude’, or ‘the Promethean urge’. According to Sandel, human enhancement and genetic engineering ‘… represent a kind of hyperagency – a Promethean aspiration to remake nature, including human nature, to serve our purposes and satisfy our desires. The problem is not the drift to mechanism but the drive to mastery. And what the drive to mastery misses and many even destroy is an appreciation of the gifted character of human powers and achievements’ (‘The Case against Perfection’, in J. Savulescu and N. Bostrom (eds.) Human Enhancement, OUP 2012, p. 78). Hamilton worries about geoengineers who desire ‘total domination of the planet’. He describes this desire as a ‘Promethean urge named after the Greek titan who gave to humans the tools of technological mastery’ (Earthmasters, Yale 2013, p. 18). Continue reading


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