Written by Dr Chris Gyngell
Last year, the first truly novel synthetic life form was created. The Minimal Cell created by the Venter Lab, contains the smallest genome of any known independent organism. While the first synthetic microbe was created in 2010, that was simply a like for like synthetic copy of the genome of an existing bacterium. Nothing like the Minimal Cell exists in nature.
This great advance in synthetic biology comes at a time where natural life forms are being manipulated in ways never seen before. The CRISPR gene editing system has been used to create hulk-like dogs, malaria proof mosquitoes, drought resistant wheat and hornless cows. The list of CRISPR-altered animals grows by the month. Continue reading
Written by Dr Christopher Gyngell
This article originally appeared on the OMS website
The Nuffield Council of Bioethics released a report last Friday outlining the key ethical issues raised by genome editing technologies.
Genome editing (GE) is a powerful, and extremely rapidly developing technology. It uses engineered enzymes to make precise, controlled modification to DNA. It has the potential to radically transform many industries, including medicine, agriculture and ecology. Despite only being developed in the past few years’, GE has already been used to create malaria-fighting mosquitoes, drought resistant wheat, hornless cows and cancer killing immune cells. The potential applications of GE in a decade are difficult to imagine. It raises a wide range of ethical issues that require careful scrutiny. Continue reading
Written by Charles Dupras and Vardit Ravitsky
Bioethics Programs, School of Public Health, University of Montreal
Environmental epigenetics is a rising field of scientific research that has been receiving much attention. It explores how exposure to various physical and social environments (e.g. pollution or social adversity) affects gene expression and, eventually, our health. Environmental epigenetics can sometimes explain why some of us carry increased risks of developing specific diseases. It provides activists a powerful vocabulary to promote environmental awareness and social justice. This new vocabulary, which allows us to discuss the consequences of disparities at the molecular level, has been enthusiastically mobilized as an effective way of stimulating political will for promoting public health preventive strategies. Continue reading
Dr Christopher Gyngell (Oxford) comments on the HFEA’s decision to give green light to UK researchers to genetically modify human embryos for research. A clear analysis of the most common concerns, and a suggestion for what direction the debate should take.
Written by Dr Chris Gyngell, Dr Tom Douglas and Professor Julian Savulescu
A crucial international summit on gene editing continues today in Washington DC. Organised by the US National Academy of Sciences, National Academy of Medicine, the Chinese Academy of Sciences, and the U.K.’s Royal Society, the summit promises to be a pivotal point in the history of the gene editing technologies.
Gene editing (GE) is a truly revolutionary technology, potentially allowing the genetic bases of life to be manipulated at will. It has already been used to create malaria-fighting mosquitoes, drought resistant wheat, hornless cows and cancer killing immune cells. All this despite the fact GE only become widely used in the past few years. The potential applications of GE in a decade are difficult to imagine. It may transform the food we eat, the animals we farm, and the way we battle disease. Continue reading
Written by Jonathan Pugh
This is an unedited version of a paper by Dr Pugh which was originally published on The Conversation:
please see here to read the original article
In a startling development in ‘gene-drive’ technology, a team of researchers at the University of California have succeeded in creating hundreds of genetically modified mosquitoes that are incapable of spreading the malaria parasite to humans, and which could potentially spread this trait rapidly throughout mosquito populations in the wild. This success has the potential to be translated into a huge global health benefit. Although global malarial deaths have been in decline over the past decade or so, WHO estimates that malaria has been responsible for over 400’000 deaths this year alone. The Anopheles genus of mosquito acts as the vector for malaria, as infected Anopheles mosquitoes transmit Plasmodium parasites to humans via their bites, and it is these parasites that cause malaria. Continue reading
Written By Johanna Ahola-Launonen
University of Helsinki
In bioethical discussion, it is often debated whether or not some studies espouse genetic determinism. A recent study by Tuomas Aivelo and Anna Uitto give important insight to the matter. They studied main genetics education textbooks used in Finnish upper secondary school curricula and compared the results to other similar studies from e.g. Swedish and English textbooks. The authors found that gene models used in the textbooks are based on old “Mendelian law”-based gene models not compatible with current knowledge on gene-gene-environment-interaction. The authors also identified several types of genetic determinism, that is, weak determinism and strong determinism, which both were present in the textbooks. The somewhat intuitive remark is that genetic education has to have a strong trickle-down effect on how people understand genes, and that we should be careful not to maintain these flawed conceptions. Furthermore, it would be useful to separate the discussion on genetic determinism into the terms “weak” and “strong”, of which the strong version is undoubtedly rarer while the weak is more prevalent.
Doctors Offering ‘Gay Gene’ To Same Sex Couples Wanting Gay Children: apparently Dr. William Strider at the Fertility Center of Chicago suggests that homosexual parents should have the option of increasing the chances of their kid being homosexual:
“When straight couples have children, the majority of them want their children to be straight as well. That is why most straight parents have trouble accepting it when their children announce to them that they are gay,” … “So it only makes sense that same-sex couples would want children that carried out their same family values of homosexuality.”
The article is likely reporting wrong on what method would be used: germline manipulation sounds like a unproven and risky approach, while PGD is a proven technique that could presumably select based on X-chromosome sequence. And given the topic it is not implausible that Dr. Strider is being misquoted. But let’s take everything at face value: would it be ethical to select for sexual preference?
On Thursday 16th October, Professor Kenneth Kendler delivered his second (and final) Loebel Lecture, entitled ‘The dappled causal world for psychiatric disorders: implications for psychiatric nosology’. You can view it online here or listen here.
Whilst Kendler’s first lecture – summarised by Roger Crisp here – focused on empirical issues, the second lecture was more philosophical. Kendler’s key question in the second lecture could perhaps be formulated as: Given the complex aetiology of mental disorders, how can we best understand and explain how they arise? Continue reading
The Genetic Epidemiology of Psychiatric and Substance Abuse Disorders: Multiple Levels, Interactions and Causal Loops
What causes psychiatric disorders, such as depression or alcohol abuse disorders? It’s obvious that background and upbringing often play a significant role, as do life events, such as losing one’s spouse or one’s job. And we also know now that genetic propensities are important. But how do these different factors inter-relate with one another? For over three decades, these issues have been at the centre of the research of Oxford’s first Loebel Lecturer, Professor Kenneth Kendler.
Professor Kendler is one of the world’s leading, and most highly cited, psychiatric researchers. He uses a range of methods, including family studies, twin and adoption studies, and molecular genetics. He also has a serious interest in the philosophy of psychiatry. His first Loebel Lecture — The Genetic Epidemiology of Psychiatric and Substance Abuse Disorders: Multiple Levels, Interactions and Causal Loops – was presented at the Oxford Martin School on Wednesday 15 October 2014, and is now available on Youtube and as an MP3 audio file. Continue reading