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Anders Sandberg’s Posts

Speaking truth to power

The sacking of Professor David Nutt from the Advisory Council on the Misuse of Drugs has led to a spirited row between politicians and scientists. Colleagues in ACMD are resigning, refusing to be used as mere rubber stamps for pre-determined agendas. The home secretary seems to want to reorganize it to his liking.

The origin of the conflict is Nutt's staunch harm-reduction and evidence based policy position: he thinks drugs should be legally classified by the harm they do, not so much by political expediency. Alcohol and tobacco are more harmful than cannabis, taking ecstasy appears to be less risky than horse riding (when counting injuries and death). Hence he has criticised policies ministers for upgrading medically less harmful drugs. While certainly controversial in the anti-drug community his arguments appear to be based on solid science. As a scientist he should also sound the alarm if the government is "devaluing and distorting" the scientific evidence.

Alan Johnson sees things differently: "He was asked to go because he cannot be both a government adviser and a campaigner against government policy." The role of an advisor is only to advice, while the government decides policy. But if the policy is against the evidence, should not the advisor advise to change the policy?

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If God hates the Higgs boson, we can build paradise on Earth

The Large Hadron Collider is an amazing scientific tool. And although it is still not up and running it produces a steady stream of exciting news – because when the experimentalists are busy with repairs the theorists are at play. New York Times brings us the story about a theory that suggests that the accelerator is being sabotaged from the future.

The idea, presented by Holger Nielsen and Masao Ninomiya in two papers (paper 1, paper 2) is that (based on some very speculative physics) there could be a form of future-to-past signal that conspires to keep futures with much Higgs production unlikely. Things will seemingly randomly arrange themselves so that the LHC doesn't get turned on, and there are no Higgs particles. The authors even suggest that one can use this influence to check the theory: make a binding agreement that the LHC will not be turned on if eleven thrown dice all come up ones (a one in 3 billion chance). If the dice do come up all ones when the CERN director throws them, that is actually evidence for the theory. This might be evidence that theoretical physics still has the edge on philosophy in strangeness.

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Protecting our borders with snake oil

The UK Borders Agency has recently come under fire for looking into the use of DNA tests and isotope analysis to determine the true nationality of asylum seekers. It is not just refugee support groups who are outraged, scientists are equally upset (perhaps more). The problems are many: there is no reason to think ancestry and ethnicity fits with nationality, the relevant genetics and isotope data is noisy, the research may not have been vetted for reliability, and it is not inconceivable that noise in the tests could be used as excuses for dismissing people who actually have valid asylum reasons (like linguistic tests occasionally do).

The project is unfortunately just the latest example that governments may be too eager to buy snake oil: on this blog I have previously criticized the use of voice-based lie detectors, the legal use of fMRI to determine guilt, ethics for military robots, pre-emptive DNA testing and electronic voting machines. The problem here is not that these technologies can't work, but that they are deployed far earlier than any careful demonstration that they actually work well enough to fulfil their purpose. It is a "science fact" problem: it is hard these days to tell what has proven to work, what is being developed and what remains a theoretical possibility. Especially when it is being pushed by enthusiastic researchers and salesmen.

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Supercoach and the MRI machine

Are there neuroethical issues in sports? Dr Judy Illes thinks so, in a talk given in Canada on September 17. People are using neuroimaging to assess ability (which may also pick up unsuspected pathologies in the brain), intervening against depression in athletes, and perhaps using deep brain stimulation for enhancing motor performance. Does enhanced training methods pose a new problem for sport?

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Academic freedom isn’t free

Should scientists be allowed to publish anything, even when it is wrong? And should there be journals willing to accept everything, as long as it seems interesting enough? That is the core of a debate that has blossomed since the journal Medical Hypotheses published two aids-denialist papers. Medical Hypotheses is a deliberately non-peer reviewed journal: the editor decides whether to publish not based on whether papers are true but whether they are bold, potentially interesting, or able to provoke useful discussion. HIV researchers strongly objected to the two papers, making the publisher Elsevier withdraw them. Now there are arguments for removing Medical Hypotheses from PubMed, the index of medical literature. Ben Goldacre of Bad Science and Bruce G Charlton, editor of Medical Hypotheses, debate the affair on Goldacre's blog. Are there scientific papers that are so bad that there should not be any journal outlet for them?

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Longer life, more trouble?

An article in the Times argues that life extension will bring us problems: long-lived people will bankrupt the NHS, pensions would become expensive, the pension age would need to be changed, there would be a pressure for resources and life would become meaningless. It is a surprisingly common criticism that would never be levelled at… Read More »Longer life, more trouble?

Non-lethal, yet dangerous: neuroactive agents

An article and editorial in Nature warns about the militarization of agents that alter mental states. While traditional chemical weapons are intended to hurt or kill people, these agents are intended to disable. For example, they might induce confusion, sleepiness or calm. The Chemical Weapons Convention contain a loophole for using biochemical agents for law enforcement including domestic riot control, and there is a push from some quarters to amend it to allow novel incapacitating agents. Is disabling agents just an extension of other forms of non-lethal force, or is this a slippery path we should avoid?

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Four… three… two… one… I am now authorized to use physical force!

Noel Sharkey, Professor of Artificial
Intelligence and Robotics at the University of Sheffield, warns that we are well on our way to get military killer robots that have great autonomy in applying deadly force. Current military "robots" such as UAVs have limited autonomy. They are
remotely controlled by humans, but increasingly given ability to
patrol, find targets and attack on their own. It would be a natural
progression to give them increasingly free reign, with the humans
merely granting permission – but in an active situation human reactions
might be too slow. Will the current convention that a properly trained
military human operator has to make the final decision still hold true
in the future?

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A tiny step forward

Researchers have managed to produce live-born mice (original article) descended from induced pluripotent stem cells (IPS cells), cells taken from adult animals and treated to become stem cells. That individuals could be produced from embryonic stem cells was already known, but this proves that the IPS cells can produce all kinds of cells in an adult body. Good news for people uneasy about the need for embryonic stem cells… or is it?

If one argues that it is wrong to use embryonic stem cells because embryos carry moral rights, then the question is whether the creation of IPS cells produce something that also has moral rights.

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Hunger for long life: the ethics of caloric restriction experiments

This has been a good week for life extension research, with the Nature paper Rapamycin fed late in life extends lifespan in genetically heterogeneous mice by Harrison et al. (free News and Views) showing that the drug boosts lifespan in middle aged mice, and Science countering with Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys by Colman et al. showing that in a 20-year longitudinal study rhesus monkeys do seem to benefit from caloric restriction (CR). CR involves keeping the energy intake low, but not so low that it induces starvation.

Not everybody seems to like the experiment. The Swedish major newspaper Dagens Nyheter had an article by Per Snaprud
that appeared to criticise the monkey experiment on ethical grounds. He
quotes Mats Spångberg, chief veterinarian at the Swedish Institute for
Infectious Disease Control, who doubts the experiment would have been
approved in Sweden. The only use of monkeys in Swedish research is AIDS
vaccine research. The article concludes by stating that the virus kills
2 million people every year, 270,000 of whose are children.

But ageing kills 100,000 people worldwide each day directly or indirectly. 100% of humans and monkeys are "infected".

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