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Research Ethics

Animal experimentation: morally acceptable, or just the way things always have been?

Following
the announcement last week that Oxford University’s controversial Biomedical
Sciences building
is now complete and will be open for business in mid-2009, the ethical issues
surrounding the use of animals for scientific experimentation have been
revisited in the media—see, for example, here ,
here,
and here.

The number
of animals used per year in scientific experiments worldwide has been estimated
at 200 million—well in excess of the population of Brazil and over three times that of the United Kingdom. If we take the importance of an ethical issue
to depend in part on how many subjects it affects, then, the ethics of animal
experimentation at the very least warrants consideration alongside some of the
most important issues in this country today, and arguably exceeds them in
importance. So, what is being done to address
this issue?

Read More »Animal experimentation: morally acceptable, or just the way things always have been?

Hacking the spammers

Why is there spam? The simple answer is that "there is a sucker born every minute" and email is cheap enough to reach millions of potential suckers who might want to buy Viagra, sure-fire investments and fake Rolexes. A new study has discovered that it is enough with one response to every 12.5 million emails sent is enough to be profitable. The most interesting about the study was how it was done: by hacking the spammers own network. But is it OK to hack in order to understand spam?

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The price of ignorance: the Durham study and research ethics

Ben Goldacre (who seems to be one of this blog’s favorite
sources) tears into the Durham fish oil trial. A while ago Durham County together with the company Equazen decided
to test whether giving omega-3 supplements would improve the GCSE scores of
children. Unfortunately there were clear problems with the trial design. In the
face of criticism the organisations involved refused to give out information on
the experimental setup and even claimed not to be running it as a trial (despite numerous statements to the
press). GCSE scores did not generally increase. Despite this, now positive results are claimed – largely because what is measured has been changed to suit
the data. The most vexing thing about the whole affair is that the
trial could have been done in a proper manner for the same amount of money.

Read More »The price of ignorance: the Durham study and research ethics

Publishing Negative Research Results

Ben Goldacre, in the Guardian this weekend, noticed the range of headlines on health and health risks that are to be found in the media. He mentions, among others, the rise of ‘manorexia’, the failure of water to induce weight loss and the dangers of antibiotics to prevent premature birth. I found a couple more: It turns out that dark chocolate can reduce the risk of heart attacks, vegetable rich diets and in particular vegetables like broccoli reduce the chance of heart disease and stroke and turmeric, the spice that makes curries yellow, can reduce the size of hemorrhagic stroke.

It’s quite striking what research is done!

Read More »Publishing Negative Research Results

Needles in Haystacks and Individuals in DNA Pools

An article recently published on PLOS Genetics showing that (and how) individuals can be identified by their DNA within large publicly accessible pools DNA has led to genetic data being removed from publicly accessible websites by the NIH and the Wellcome Trust. As one geneticist quoted in Science put it “We have a false sense of security with pooled data.”

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‘Anyone who thinks the Large Hadron Collider will destroy the world is a t**t.’

This week is Big Bang Week at the BBC, with various programmes devoted to the switch-on of CERN’s Large Hadron Collider (LHC) on Wednesday morning.  Many of these programmes are covered in this week’s issue of the Radio Times—the BBC’s listings magazine—which also features a short interview with Professor Brian Cox, chair of particle physics at the University of Manchester.  Asked about concerns that the LHC could destroy the earth, he replies:

‘The nonsense you find on the web about “doomsday scenarios” is conspiracy theory rubbish generated by a small group of nutters, primarily on the other side of the Atlantic.  These people also think that the Theory of Relativity is a Jewish conspiracy and that America didn’t land on the Moon.  Both are more likely, by the way, than the LHC destroying the world.  I’m slightly irritated, because this non-story is symptomatic of a larger mistrust in science, particularly in the US, which includes things like intelligent design. [… A]nyone who thinks the LHC will destroy the world is a t**t.’ (Final word censored by Radio Times.) [1]

Read More »‘Anyone who thinks the Large Hadron Collider will destroy the world is a t**t.’

Slaves to consent?

Nature reports that in response to analysis done by bioethicist Robert Streiffer (and published in the Hastings Center Report), Stanford University may withdraw the use for research of several of its publicly funded stem cell lines because of concerns about consent. In 2001 President Bush decreed that only lines already in existence would be eligible for federal funding – 21 lines were subsequently approved by the NIH.

Read More »Slaves to consent?

Reproductive science: is there something we’re missing?

Thirty
years after the first test-tube baby, Nature
asks various experts for their views on what the next thirty years of
reproductive medicine will bring.
Some of the more startling predictions are:

  • No more infertility, with both children and 100-year-olds able to have children
  • Embryos created from stem cells, increasing the ease of embryo research and genetic engineering of children
  • … with the resulting greater availability of embryos making it easier to create cloned humans
  • Artificial wombs, enabling babies to develop outside the mother’s body
  • … which, some worry, could become compulsory as an alternative to abortion, or to avoid premature birth or fetal alcohol syndrome
  • ‘Genetic cassettes’ implanted in embryos to counteract the effects of inherited diseases
  • Increase in litigation following evidence that IVF babies may later suffer adverse effects from the environment in which they were grown as embryos

Read More »Reproductive science: is there something we’re missing?

The Choice to Have Artificial Blood: Less than the Best?

Controversy has erupted around whether experiments to test artificial blood should stop. Experimental blood substitutes raised the risk of heart attack and death, yet U.S. regulators allowed human testing to continue despite warning signs, says a scathing new report.

Blood substitutes, or artificial blood, could be stored for years without refrigeration, and be used in battlefield situations. It would carry no risk risk of infection with hepatitis or HIV. It would be an acceptable alternative to Jehovah’s Witnesses who refuse life saving blood transfusions.
In a new report, researchers pooled data from 16 separate studies of five different blood substitutes, involving over 3,700 patients. Researchers found a 30 percent higher risk of death overall for patients who received transfusions using the blood substitutes. The risk of heart attack was nearly tripled in the groups receiving blood substitutes.

“Experts speculate that hemoglobin in the blood substitutes scavenges nitric oxide from the blood, causing blood vessels to constrict and sticky platelets to build up. That increases the risk of heart attacks.”

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The Dignity of the Carrot

What are you allowed to do to plants? At least in Switzerland you are not allowed to do research that deeply offend the dignity of plants. The Swiss federal Gene Technology Law stipulates that any scientific research should respect the "dignity of creation". All plant biotechnology grant applications must now state how they take plant dignity into consideration, confusing researchers.  The Federal Ethics Committee on Non-Human Biotechnology (ECNH) have issued some guidelines (pdf) which make the situation even more confusing. Neither humans nor plants are likely to be helped.

Read More »The Dignity of the Carrot