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Japan to Allow Human-Animal Hybrids to be Brought to Term

By Mackenzie Graham

The article was originally published at the Conversation

Around the world thousands of people are on organ donor waiting lists. While some of those people will receive the organ transplants they need in time, the sad reality is that many will die waiting. But controversial new research may provide a way to address this crisis.

Japan has recently overturned its ban on the creation of human-animal hybrids, or “chimeras”, and approved a request by researchers from the University of Tokyo to create a human-mouse hybrid.

Scientists will attempt to grow a human pancreas inside a mouse, using a certain kind of stem cell known as “induced pluripotent stem cells”. These are cells that can grow into almost any kind of cell. The stem cells will be injected into a mouse embryo, which has been genetically modified to be incapable of producing a pancreas using its own cells. This hybrid embryo is then implanted in a mouse surrogate and allowed to grow. The goal is to eventually grow a human pancreas in a larger animal – such as a pig – which can be transplanted into a human.

Read More »Japan to Allow Human-Animal Hybrids to be Brought to Term

Human In Vitro Gametogenesis and the Same-Sex Marriage Debate

Written by César Palacios-González

It seems that in the not-so-distant future, scientists will be able to create functional human gametes (i.e. eggs and sperm) in a laboratory setting. In other words, they will be able to create human gametes outside of the human body. And just as there is in vitro fertilization (IVF), there will be in vitro gametogenesis (IVG). This means that our already long list of human reproductive acronyms –IVF, PGD, ICSI, PNT, PBT1, PBT2, MST, UTx, CT, etc.–  will get a bit longer. At present, some of the best biology labs from around the world are actively working on how to achieve such goal, and non-human animal models have shown some amazing results.

For starters, scientists have successfully derived in a laboratory setting mouse oocyte-like cells and sperm-like cells from induced pluripotent stem cells and embryonic stem cells. And, most surprisingly, they have been able to create what has been called “cross-sex gametes”. This means that they have been able to create sperm-like cells from female mice, and oocyte-like cells from male mice (I use the terms ‘sperm-like’ and ‘oocyte-like’ because these cells are not identical to naturally occurring gametes). Some of such cross-sex gametes have, in turn, been capable of producing live offspring.Read More »Human In Vitro Gametogenesis and the Same-Sex Marriage Debate

Baby, It’s Cold Outside

By Mackenzie Graham

In late November, a radio station in Cleveland Ohio announced it would be removing the song ‘Baby, It’s Cold Outside’ from its holiday playlist, in response to listener complaints. Several other radio stations followed, including Canadian broadcasters Bell Media, CBC Radio and Rogers Media. These decisions proved divisive among listeners, however, with many of the US broadcasters, as well as the CBC, quickly reversing course and reinstating the song after conducting online listener polls.

The song was written in 1944 by Frank Loesser, as a duet that he regularly performed with his wife Lynn Garland at Hollywood celebrity parties. In 1949, Loesser sold the song to MGM Studios, who used it in the film Neptune’s Daughter, where it won the Academy Award for Best Original Song that same year. It has been re-recorded by more than 50 artists since that time, most recently in 2018, and is a staple of popular radio during the Christmas season, due to its wintery theme.

In the lyrics of the song, a party guest (typically sung by a female voice) and the party host (typically a male voice) sing back and forth about whether the guest should stay for ‘one more drink,’ or venture home (despite it being, presumably, quite cold outside). The female voice sings lines like ‘I ought to say no, no, no’, ‘what’s in this drink’, ‘you’re very pushy you know’, and ‘the answer is no’, while the male voice sings lines like ‘mind if I move in closer’, ‘what’s the sense of hurting my pride’, and ‘gosh your lips look delicious.’

Read More »Baby, It’s Cold Outside

Against Conscientious Objection In Health Care: A Counterdeclaration And Reply To Oderberg

Alberto Giubilini (Wellcome Centre for Ethics and Humanities, University of Oxford) and

Julian Savulescu (Uehiro Centre for Practical Ethics, University of Oxford)

Conscientious objection in health care – that is, healthcare practitioners objecting to performing certain legal, safe, and beneficial medical procedures (e.g. abortion) that a patient requests by appealing to their personal moral values – is one of the most debated topics in medical ethics at present time. Although at the moment doctors’ private conscience enjoys a lot of legal protection – most laws that make abortion legal contain clauses that exempt doctors from performing the procedure if they so wish. We have provided reasons, both in this forum and in our academic work, for why we think that conscientious objection in health care is not morally permissible and should not be allowed in the case of procedures that are legal, safe, beneficial, autonomously requested by patients and, more generally, consistent with the standards of good medical practice (see e.g. Savulescu 2006, Savulescu and Schuklenk 2017, Giubilini 2014, Giubilini 2017). Some people disagree and advance reasons for the opposite view. One of the scholars who has more clearly and straightforwardly articulated the principles and reasons in support of conscientious objection in health care is Professor Oderberg of Reading University. Prof Oderberg was recently invited to debate the issue with Julian Savulescu at the Masters Course in Practical Ethics run by the Uehiro Centre here at the University of Oxford. On that occasion, Prof Oderberg’s defense of conscientious objection centred around a series of principles and considerations that he very effectively formulated in the 17 main points that constitute his “Declaration in support of conscientious objection in health care”, published on the University of Reading website and which is available for people who agree with him to sign.Read More »Against Conscientious Objection In Health Care: A Counterdeclaration And Reply To Oderberg

Fetal Reduction in a Multiple Pregnancy: the Case of Identical Twins

Written by Elizabeth Crisp and Roger Crisp

When a woman aborts a single fetus, that abortion can be a morally troubling experience for her. What about a situation in which a woman is pregnant with more than one fetus, perhaps identical twins, and wishes to abort just one of them – that is, engage in what is sometimes called ‘fetal reduction’ in a ‘multiple pregnancy’?Read More »Fetal Reduction in a Multiple Pregnancy: the Case of Identical Twins

The Psychology of Uncertainty, Vaccinations, and Protecting the Most Vulnerable: Was Rawls Right After All?

written by Andreas Kappes (@AnKappes), Anne-Marie Nußberger (@amnussberger ), Molly Crockett (@mollycrockett ) & Julian Savulescu  (@juliansavulescu)

Measles is making a comeback in Britain and Europe with numbers rising to record levels this year. Last year in Europe, measles killed 35 people, including young children . The re-emergence of measles can be traced to falling rates of vaccination and might make you want to re-think your summer plans. Crowded environments with low levels of hygiene, also known as summer festivals, are something to avoid if unsure about whether you have been properly vaccinated. And maybe re-think going for holidays to Romania, Italy and Greece, the countries with the highest rates of measles outbreaks this year.

But of course, even if you are not vaccinated, your chances of getting measles are low. And if you are infected, dying from measles is rare. The people that die during measles outbreaks are vulnerable babies that are too young to be vaccinated and unvaccinated people with compromised immune systems. And what are the chances that you infect one of these vulnerable people? Extremely low. Your intuition then might be that even if you are unsure about your vaccination status, the low odds don’t seem to justify the effort to engage with the NHS or any other health care provider. Maximize your benefits, and others will surely be fine. Individually, this feels right, but for the communities and countries we live in, this is disastrous, slowly eroding herd immunity that protects the most vulnerable.

Read More »The Psychology of Uncertainty, Vaccinations, and Protecting the Most Vulnerable: Was Rawls Right After All?

Free Will Sceptics: We’re Not So Bad.

Written by Neil Levy

A number of philosophers and psychologists suggest that belief in free will – whether it is true or not – is important, because it promotes prosocial behavior. People who disbelieve in free will might become fatalists, holding that their choices make no difference to how events play out, because they’re already determined (say). They might think that our lives lack value, in the absence of free will, and therefore that they do not deserve respect. There is, on most accounts of free will, a close link between free will and moral responsibility: if we lack free will, we’re not morally responsible. This link provides a third path whereby lack of belief in free will might lead to antisocial behavior: because people believe that they do not deserve blame for acting badly, they might be less motivated to act well.Read More »Free Will Sceptics: We’re Not So Bad.

Spineless Ethics

Written by Roger Crisp

Last week, at a seminar organized jointly by the Oxford Uehiro Centre and the Wellcome Centre for Ethics and Humanities, Prof. Irina Mikhalevich presented a fascinating preview of a paper (‘Minds Without Spines: Toward a More Comprehensive Animal Ethics’) which forms part of a project she has been working on with Prof. Russell Powell.Read More »Spineless Ethics

The Utilitarian’s Guide to the FIFA World Cup

By Hazem Zohny

For those suspicious of sentiments like national pride, or who simply fail to feel emotionally engaged by a sporting team representing a bit of territory on the planet, the World Cup season can feel alienating. It is a global phenomenon that can be difficult to avoid, and you may rightly feel tired of being that person lecturing their friends and colleagues about how football is the true opium of the masses.

If so, you might as well breathe in the fumes with everyone and enjoy the ride. But given your deep-seated apathy about the World Cup, who should you support, and why? Fortunately, that moral theory Bernard Williams dismissed in 1973 – hoping “the day cannot be too far off in which we hear no more of it” – is here to help.

Utilitarianism is about the impartial maximization of happiness. With over 3 billion humans allowing a ball passed around on a screen to puppeteer their emotions over the next month, there is much happiness and misery to be experienced around the globe. A World Cup-apathetic utilitarian ought to support those teams that will likely maximize net happiness by winning.

How do we determine who those teams are?

Read More »The Utilitarian’s Guide to the FIFA World Cup