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A Nasty Dilemma for NICE

After a prolonged disagreement with patient groups, the NHS’s funding guidance body, NICE, has approved the £10,000-an-eye blindness treatment, Lucentis. The drug has been shown to halt the progression of wet age-related macular degeneration (AMD), the most common cause of blindness in developed countries. But as the BBC  note, in approving it, NICE may have unwittingly deprived the NHS of a much cheaper alternative.

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Radical organ retrieval procedures

I wrote recently
about the controversial news that surgeons in Denver had taken organs,
including the hearts, from newborn infants who had died in intensive
care.
In recent years the retrieval of organs from patients whose hearts have
stopped (so-called donation after cardiac death, DCD) has become more
popular. In part this is because of the problem that there is a
shortage of organ donors who are brain dead. It is also because of the
recognition that when patients die after removal of life support, their
organs may still be viable for transplantation.

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When the heart stops: harvesting organs from the newly (nearly) dead

In the New England Journal of Medicine yesterday, doctors from Denver reported on three controversial cases of heart transplantation from newborn infants. These cases are striking for several reasons. They were examples of so-called ‘donation after cardiac death’ (DCD), an increasingly frequent source of organs for transplantation, but done very rarely in newborns. They are controversial because the transplanted organs were hearts that were ‘restarted’ in recipients after they had stopped in the donor. Transplant surgeons waited only a relatively short period after the donor’s heart had stopped (75 seconds) before starting the organ retrieval process. These transplants raise serious questions about the diagnosis and definition of death.

Read More »When the heart stops: harvesting organs from the newly (nearly) dead

Would you rather be invisible or be able to fly? (Or: are you a sneaky superhero?)

If, like
me, you were one of the kids whose preferred superpower was invisibility, you
may soon be in luck. The BBC reports
today
that US scientists have
created a material that could one day be used to make people and objects invisible. The material, which has so far been created
only on a microscopic scale, neither absorbs nor reflects light,
meaning that anyone looking at an object covered in it would see what
lies behind the object rather than the object itself. It’s likely that such technology will be
snapped up first by the military, but perhaps, in years to come, invisibility
cloaks will be available to all.

For some,
the idea of being invisible is distasteful. Being invisible means being able to get away with anything – and
why bother to act morally when you can be sure that you’ll never be caught
out? In this case, would a world full of
people who can turn invisible at the drop of a hat be a world full of thieves,
cheats, and sneaks?

Read More »Would you rather be invisible or be able to fly? (Or: are you a sneaky superhero?)

Cold and Calculating NICE

Yesterday’s Daily Mail online contains an opinion piece bemoaning the decision by NICE – the UK body responsible for rationing healthcare resources – to decline funding for four new treatments for Kidney Cancer. The Mail complains:

…what does NICE offer by way of explanation? A cold, calculating statement that, while the drugs work for many of those with advanced kidney cancer, they are not ‘cost-effective’.

What a clinical way to assess whether a person should be afforded precious extra months and years of life, or consigned to a ‘death sentence’.

I don’t want to defend NICE’s decision in this particular case, but the Mail’s attack on NICE’s "clinical" decision-making process is clearly unjustified.

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Slaves to consent?

Nature reports that in response to analysis done by bioethicist Robert Streiffer (and published in the Hastings Center Report), Stanford University may withdraw the use for research of several of its publicly funded stem cell lines because of concerns about consent. In 2001 President Bush decreed that only lines already in existence would be eligible for federal funding – 21 lines were subsequently approved by the NIH.

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Should Karadzic be Punished?

Yesterday the world celebrated the arrest of Radovan Karadzic, the ex-Bosnian Serb leader who has twice been indicted by the UN War Crimes Tribunal in the Hague, and is charged with – among other atrocities — ordering his forces to kill at least 7,500 Muslim men and boys in Srebenica in July 1995 as part of a campaign to terrorize and demoralize the population.

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Reproductive science: is there something we’re missing?

Thirty
years after the first test-tube baby, Nature
asks various experts for their views on what the next thirty years of
reproductive medicine will bring
.
Some of the more startling predictions are:

  • No more infertility, with both children and 100-year-olds able to have children
  • Embryos created from stem cells, increasing the ease of embryo research and genetic engineering of children
  • … with the resulting greater availability of embryos making it easier to create cloned humans
  • Artificial wombs, enabling babies to develop outside the mother’s body
  • … which, some worry, could become compulsory as an alternative to abortion, or to avoid premature birth or fetal alcohol syndrome
  • ‘Genetic cassettes’ implanted in embryos to counteract the effects of inherited diseases
  • Increase in litigation following evidence that IVF babies may later suffer adverse effects from the environment in which they were grown as embryos

Read More »Reproductive science: is there something we’re missing?