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A Nasty Dilemma for NICE

A Nasty Dilemma for NICE

After a prolonged disagreement with patient groups, the NHS’s funding guidance body, NICE, has approved the £10,000-an-eye blindness treatment, Lucentis. The drug has been shown to halt the progression of wet age-related macular degeneration (AMD), the most common cause of blindness in developed countries. But as the BBC  note, in approving it, NICE may have unwittingly deprived the NHS of a much cheaper alternative.

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The truth about saving water

The last few years have seen some very bad droughts. In the UK, the drought of 2004-2006 was severe enough to nearly require the shutting down of domestic water in London and the fetching of water from public wells (called standpipes). Australia has been suffering from its own decade long drought with devastating consequences. As a result, water-awareness in both countries has been rising. People are at least dimly aware of ideas for saving water, such as turning off the tap while brushing one’s teeth. In Australia there was even a government sponsored advertisement recommending taking showers with someone else. However, as a recent report from the World Wildlife Fund shows, even if we stop showering altogether, we will still be using an unsustainable amount of fresh water.

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Doctors or Resource Allocators?

A recent survey by Myeloma UK, and reported on the BBC website, suggests that many doctors do not tell patients about drugs that may be beneficial and which are licensed in the UK. The trouble is that the drugs have not yet been approved by NICE and so may be difficult to obtain on the NHS. This seems to suggest that something is wrong with the way in which NICE functions with respect to licensing and that doctors are in some way complicit.

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Radical organ retrieval procedures

I wrote recently
about the controversial news that surgeons in Denver had taken organs,
including the hearts, from newborn infants who had died in intensive
care.
In recent years the retrieval of organs from patients whose hearts have
stopped (so-called donation after cardiac death, DCD) has become more
popular. In part this is because of the problem that there is a
shortage of organ donors who are brain dead. It is also because of the
recognition that when patients die after removal of life support, their
organs may still be viable for transplantation.

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The Stuff Dreams Are Made Of

Studies of the content of dreams confirm what most of us already suspect: dreams are more likely to be nasty than pleasant, or as the researchers put it, “negative dream contents are more frequent than corresponding positive dream contents”. A recent study reports that threatening experiences are more frequent and intense in dreams than in real life. All this is in line with the entertaining (and not implausible) ‘threat simulation theory’ of dreams, according to which the evolutionary function of dreams is to simulate threats so that our ancestors could spend their nights rehearsing attacks by enemies and predators.

So dreams have a serious negative bias. All of this might have been extremely useful back then. But an unwelcome consequence is that we spend a large portion of our life in pointless misery. Clinical depression is often understood as a disposition to obsessively accentuate the negative. It seems all of us are clinically depressed during certain hours of the night. Think of a human life and how many hours of sleep it contains. Of these, many are spent dreaming. And most of these dreams are unpleasant in different ways. If we add all this up, dreaming makes our lives significantly worse, on balance. Shouldn’t we do something about this?

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How to Improve on Bolt’s Performance

You might think after Usain Bolt’s almost superhuman performances in the 100 and 200 m that the war on doping has been won. However winning one battle is not winning the war. As the example of Lyudmila Blonska shows, doping is still occurring. It is almost certain that there are other medals and world records that were achieved by athletes who were doping but were not caught. The sophistication  of the technology means that just because we are picking up fewer positive tests, it does not mean that there are fewer athletes doping

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Silicon dreams: digital drugs and regulation

A new worry has hit parents: digital drugs. The idea is that sounds can affect brain states, so by listening to the right kind of sounds desired brain states can be induced – relaxation, concentration, happiness, PMS relief or why not hallucinations? Apparently "idosers" walk around high on sound. Just the right thing for a summer moral panic – kids, computers, drugs and pseudoscience.

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When the heart stops: harvesting organs from the newly (nearly) dead

In the New England Journal of Medicine yesterday, doctors from Denver reported on three controversial cases of heart transplantation from newborn infants. These cases are striking for several reasons. They were examples of so-called ‘donation after cardiac death’ (DCD), an increasingly frequent source of organs for transplantation, but done very rarely in newborns. They are controversial because the transplanted organs were hearts that were ‘restarted’ in recipients after they had stopped in the donor. Transplant surgeons waited only a relatively short period after the donor’s heart had stopped (75 seconds) before starting the organ retrieval process. These transplants raise serious questions about the diagnosis and definition of death.

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Postcode lotteries

In its just-published report Taking Exception on the allocation of cancer drugs by UK Primary Care Trusts, the Rarer Cancers Forum (http://www.rarercancers.org.uk)  provides further evidence of a ‘postcode lottery’ operating within the UK National Health Service. For example (p. 26), the Mid-Essex PCT has granted 96% of requests to its ‘exceptional cases panel’, while neighbouring South-West Essex PCT has granted none.

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Would you rather be invisible or be able to fly? (Or: are you a sneaky superhero?)

If, like
me, you were one of the kids whose preferred superpower was invisibility, you
may soon be in luck. The BBC reports
today
that US scientists have
created a material that could one day be used to make people and objects invisible. The material, which has so far been created
only on a microscopic scale, neither absorbs nor reflects light,
meaning that anyone looking at an object covered in it would see what
lies behind the object rather than the object itself. It’s likely that such technology will be
snapped up first by the military, but perhaps, in years to come, invisibility
cloaks will be available to all.

For some,
the idea of being invisible is distasteful. Being invisible means being able to get away with anything – and
why bother to act morally when you can be sure that you’ll never be caught
out? In this case, would a world full of
people who can turn invisible at the drop of a hat be a world full of thieves,
cheats, and sneaks?

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