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The price of ignorance: the Durham study and research ethics

The price of ignorance: the Durham study and research ethics

Ben Goldacre (who seems to be one of this blog’s favorite
sources) tears into the Durham fish oil trial. A while ago Durham County together with the company Equazen decided
to test whether giving omega-3 supplements would improve the GCSE scores of
children. Unfortunately there were clear problems with the trial design. In the
face of criticism the organisations involved refused to give out information on
the experimental setup and even claimed not to be running it as a trial (despite numerous statements to the
press). GCSE scores did not generally increase. Despite this, now positive results are claimed – largely because what is measured has been changed to suit
the data. The most vexing thing about the whole affair is that the
trial could have been done in a proper manner for the same amount of money.

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Publishing Negative Research Results

Ben Goldacre, in the Guardian this weekend, noticed the range of headlines on health and health risks that are to be found in the media. He mentions, among others, the rise of ‘manorexia’, the failure of water to induce weight loss and the dangers of antibiotics to prevent premature birth. I found a couple more: It turns out that dark chocolate can reduce the risk of heart attacks, vegetable rich diets and in particular vegetables like broccoli reduce the chance of heart disease and stroke and turmeric, the spice that makes curries yellow, can reduce the size of hemorrhagic stroke.

It’s quite striking what research is done!

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DON’T PANIC

It has been an extraordinary week in the financial markets of the
world. With the collapse of major international financial institutions,
and governments forced to intervene by propping up ailing insurers or
authorising the merger of banks, newspaper headlines have competed to
convey the scale and significance of the crisis. But there is a
difficult line for newspaper editors and sub-editors to tread between
accurately reflecting the enormity of the market upheavals, and
contributing to the crisis. Should newspapers be censored, or censor
themselves at times of great market sensitivity or do they have a duty
to their readers to speak the truth?

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Cognitive Science Advice for Republicans and Democrats?

The upcoming US elections have revived the culture wars but so far controversy about science and biotechnology has not taken centre stage, as both candidates support stem cell research. But science is still playing a minor role in the discussion. Writing in the New York Times, the influential conservative pundit David Brooks recently gave advice to his fellow Republicans. In recent years, he argues, they have come to endorse a rampant libertarian individualism and forgotten about the importance of social connections and bonds, once a core conservative value. This form of criticism is old and familiar. What is new is the form it now takes. What is wrong is wrong about the individualist outlook, Brooks argues, is that it is false to human nature, a fact apparently revealed by recent research in cognitive science, neuroscience, genetics, and behavioural economics, which has rediscovered the ‘old truth’—“that we are intensely social creatures, deeply interconnected with one another and the idea of the lone individual rationally and willfully steering his own life course is often an illusion.”

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I suggest it was Professor Plum, in the library, with the arsenic: the unreliability of brain experience detection

A woman has been convicted in Mumbai for murder, based on a new brain-based experience detection technology. As can be predicted, many regard this as Orwellian while others hope technologies like this could transform the courtroom "as much as DNA evidence has". But there are big problems. The most obvious one is the question of whether the technology actually works, let alone works well enough to be suitable for convicting somebody. The analogy with DNA evidence points at the second big problem: the legal institutions need to learn how to use it well. There are very good reasons for experts in psychology, neuroscience and forensics are troubled by this case.

Read More »I suggest it was Professor Plum, in the library, with the arsenic: the unreliability of brain experience detection

Testing choices: weighing up risks of death and Down syndrome for fetuses

In the Observer yesterday, researchers from a major disability charity
have claimed that the risks of screening for Down syndrome during
pregnancy have been underestimated. The researchers suggest that for
every 3 fetuses with Down syndrome that are detected by screening 2
unaffected fetuses miscarry as a complication of the testing process.
Should screening be stopped? If screening continues how should
prospective parents weigh up this risk?

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Needles in Haystacks and Individuals in DNA Pools

An article recently published on PLOS Genetics showing that (and how) individuals can be identified by their DNA within large publicly accessible pools DNA has led to genetic data being removed from publicly accessible websites by the NIH and the Wellcome Trust. As one geneticist quoted in Science put it “We have a false sense of security with pooled data.”

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National Borders

An eight-year-old Iranian boy has been released after spending nearly two months in Yarl’s Wood immigration removal centre (http://www.guardian.co.uk/uk/2008/sep/06/immigration.humanrights). Child M, as he’s known, has been given body searches and now, unsurprisingly, seems to have various physical and psychiatric problems. His case is an especially clear example of the effects of national borders, and border controls, on people’s lives.

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